The pancreas supplies the major digestive enzymes that catalyze the breakdown of fats, carbohydrates, and protein so that the breakdown products can be absorbed in the upper small intestine. Although fat digestion starts in the mouth with salivary lipase, most triglycerides are digested by pancreatic lipase, which is secreted by the exocrine pancreas into the duodenum of the intestine. Pancreatic lipase cleaves triglycerides into monoglycerides and free fatty acids, which are efficiently absorbed in the upper small intestine. Some carbohydrate digestion takes place in the mouth by salivary amylase, but pancreatic amylase is the major carbohydrate-digesting enzyme. It breaks down starches into maltose and maltotriose, which are further hydrolyzed into glucose by the disaccharidases of the mucosal cells, and then absorbed. Protein digestion is initiated in the stomach by pepsin and hydrochloric acid, which denature and divide large proteins into smaller polypeptides. The addition of betaine in this formulation may help existing stomach acid better digest proteins as they enter the stomach. The pancreatic proteinases, trypsin and chymotrypsin, break down these polypeptides into free amino acids, and di-or tri-peptides, which are directly absorbed by the intestinal mucosa. Digestive Enzymes with Betaine provides high levels of catalytically active pancreatic enzymes that are specific for fats, carbohydrates, and proteins. Bromelain may act to help prevent allergens from crossing the gastrointestinal tract, and assists in the breakdown of large macromolecular protein complexes. This may reduce the chance that these complexes will leave the stomach untouched or in large fractions retaining their recognizable antigenic form that could pass through gastric or intestinal lesions thereby inducing an allergenic response.