Monograph

Help your body maintain cholesterol balance and heart health. Sytrinol™ was developed after 12 years of research, which found PMFs and tocotrienols have antioxidant and anti-inflammatory properties that assist normal cardiovascular function and cholesterol synthesis - vital to cellular function and hormone balance.
 

Description

NUTRAscriptives® Sytrinol™ contains a proprietary blend of polymethoxylated flavones (from dried fruits and orange peels) and tocotrienols (a form of vitamin E).

Research

Cardiovascular Health

Sytrinol™ contains two potent antioxidant blends that offer a wide range of cardiovascular benefits, polymethoxylated flavones (PMFs) and tocotrienols. PMFs are flavonoids that have been shown to promote normal cell growth, reduce inflammation, and support endothelial function.[1] Tocotrienols are compounds in the vitamin E group, which have exhibited strong antioxidant effects to support cardiovascular health and normal cell growth.[2]

Flavones may counteract the formation of cerebral blood clots and cardiovascular dysfunction. A longitudinal-study followed 1,950 healthy men (aged 42-60) for approximately 15 years. Results indicated subjects that consumed the highest amount of flavonoids were less likely to develop cerebral blood clots or cardiovascular dysfunction.[3] These researchers conducted a similar study reviewing the effects of flavonoids in 1,380 middle-aged men with various levels of cardiovascular health. Results indicated a high flavonoid intake was related to optimal cardiovascular health.[4]

A six-year study of 25,372 male smokers (50-60 years old) with normal cardiovascular function observed the benefits of flavones and flavonols on heart health. Results indicated subjects with the highest intake of flavone and flavonols were less likely to develop cardiovascular ailments.[5]

Chronic inflammation is often related to cardiovascular dysfunction, as inflammation influences the development of endothelial cells, smooth muscle cells, and immune cells. Tocotrienols can reduce the inflammation response allowing various arterial functions to stabilize.[6]

Cholesterol

Several studies have shown that the PMFs and tocotrienols found in Sytrinol™ have cholesterol-balancing components. Three different groups of subjects (men and women, 19 – 65 years old) with cholesterol imbalances took citrus flavonoids/tocotrienols or a placebo for four weeks. A third group was involved with a twelve-week administration. Daily treatment with citrus flavonoids/tocotrienols significantly improved cholesterol levels.[7]

One study gave 28 subjects tocotrienols and 16 subjects vitamin E for four weeks. Total cholesterol and LDL levels significantly decreased in the tocotrienol group, while the vitamin E group was unaffected.[8]

A ten-week animal study reviewed tocotrienols effects in rabbits with cholesterol imbalances. Three different groups were established to receive a normal diet, 2% cholesterol diet, or 2% cholesterol diet with tocotrienols. Researchers found that the development of lipid peroxidation was lowest in rabbits consuming a 2% cholesterol diet with tocotrienols.[9]

Another animal study found tocotrienols reduced lipid peroxidation in the blood and enhanced antioxidant activity, including superoxide dismutase (SOD). The study indicated tocotrienols' antioxidant effects could prevent blood pressure imbalances.[10]

PMFs balanced cholesterol levels in hamsters. These potent antioxidants decreased LDL cholesterol by augmenting PMF metabolites in the liver to reduce the production of lipids in the blood.[11]

Cellular Immunity

Tocotrienols' antioxidant benefits can support normal cellular proliferation. One study observed tocotrienols decreased abnormal cellular growth in the gastrointestinal tract.[12]

Insulin Balance

Individuals with insulin imbalances are often at greater risk for developing cardiovascular ailments. A sixty-day study gave tocotrienols to rats with insulin ailments finding a decline in high LDL cholesterol levels that are commonly associated with insulin imbalances.[13]

A similar study reviewed the effects of polymethoxylated flavones (PMFs) on insulin abnormalities in hamsters. Results indicated PMF decreased insulin levels and improved glucose tolerance.[14]

Additional Information – Dosage & Interactions

Suggested Use

As a dietary supplement, take one soft gel twice daily, or as directed by a physician.

Dosage

300 mg per day in divided doses

Precautions

The maximum safe dosage of this supplement has not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.

There are no known adverse reactions with proper supplementation.

Drug Interactions

Consult your physician before supplementing with Sytrinol if you are taking the following medications.

Antiplatelet drugs (aspirin, etc.); Warfarin, etc. (doses greater than 100 mg may add to anti-coagulant drug actions); Statins (may add to the cholesterol-lowering effects)

*Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References

[1] Manthey, JA, Grohmann, K, Guthrie, N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001 Feb; 8(2):135-153.

[2] Nesaretnam, K. Multitargeted therapy of cancer by tocotrienols. Cancer Lett. 2008 May 24.

[3] Mursu, J, Nurmi, T, Tuomainen, TP, et al. The intake of flavonoids and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2007 Oct; 98(4):814-818.

[4] Mursu, J, Voutilainen, S, Nurmi, T, et al. Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr. 2008 Apr; 1-6.

[5] Hirvonen, T, Pietinen, P, Virtanen, M, et al. Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology. 2001 Jan; 12(!):62-67.

[6] Osiecki, H. The role of chronic inflammation in cardiovascular disease and its regulation by nutrients. Altern Med Rev. 2004 Mar; 9(1):32-53.

[7] Roza, JM, Xian-Lui, Z, Guthrie, N. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med. 2007 Nov-Dec; 13(6):44-48.

[8] Ajuluchukwu, JN, Okubadejo, NU, et al. Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles in patients with mild hypercholesterolaemia: a preliminary report. Niger Postgrad Med J. 2007 Mar; 14(1):30-33.

[9] Nafeeza, MI, Norzana, AG, Jalaluddin, HL, Gapor, MT. The effects of a tocotrienol-rich fraction on experimentally induced atherosclerosis in the aorta of rabbits. Malays J Pathol. 2001 Jun; 23(1):17-25.

[10] Newaz, MA, Nawal, NN. Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats (SHR). Clin Exp Hypertens. 1999 Nov; 21(8):1297-1313.

[11] Kurowska, EM, Manthey, JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004 May; 52(10):2879-2886.

[12] Sun, W, Xu, W, Liu, H, et al. Gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem. 2008 Jul 3.

[13] Baliarsingh, S, Beg, ZH, Ahmad, J. The therapeutic impacts of tocotrienols in type- 2 diabetic patients with hyperlipidemia. Arthersclerosis. 2005 Oct; 182(2):367-374.

[14] Li, RW, Teriault, AG, Au, K, et al. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life Sci. 2006 Jun; 79(4):365-373.